LHDAG_HDVD3

Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal. Needs co-infection with hepatitis B virus to provide surface proteins, otherwise there is no packaging or budding. Packages the HDV ribonucleoprotein in hepatitis B virus empty particles. Interacts with both HDV genomic RNA and cytoplasmic tail of HBsAg. May inhibit viral RNA replication.

Prenylated by host farnesyl-transferase in the cytoplasm prior to nucleus translocation.

Phosphorylated at serines by host CK2 and other kinases. phosphorylation does not seem to be important for its function.

Belongs to the hepatitis delta antigen family.

• Virion
• Host nucleus
• Host nucleolus
• isoprenylated in the cytoplasm, and translocates in the nucleus possibly after phosphorylation. Translocates after to nuclear speckle, then to the ER membrane where interaction with Hepatitis B virus antigene takes place.

Large delta antigen, L-HDAg, p27

• swissprot:P29996

Proteins

24060Da