LIF
GeneName
LIF
Summary
LIF, also known as leukemia inhibitory factor or HILDA, is a 22kDa cytokine that is secreted into the extracellular region and plays a vital role in various biological processes. It is involved in cell surface receptor signalling pathways, particularly through its interactions with the LIF receptor, leading to activation of the STAT signalling pathway. LIF is expressed in multiple tissues and is essential for processes such as embryo implantation, decidualization, and blood vessel remodelling. It also influences cell morphogenesis, fibroblast proliferation, and macrophage differentiation, highlighting its importance in both developmental and immune responses.
Importance
LIF is relevant to: - Stem cell biology, as it maintains pluripotency and supports self-renewal in embryonic stem cells - Reproductive biology through its critical role in implantation and decidualisation - Cancer research, particularly in the context of leukaemia and other malignancies due to its effects on cell proliferation and differentiation - Tissue repair and regeneration, given its involvement in fibroblast and macrophage activity during wound healing - Developmental biology, especially in lung and kidney morphogenesis, where it regulates organ development and cellular differentiation.
Top Products
For researchers investigating LIF, we recommend two excellent primary antibodies. The first is the well-cited polyclonal antibody, Anti-LIF antibody (ab113262), which has garnered 23 citations, reflecting its reliability in the field. This antibody is particularly effective for Western blotting (WB) and immunocytochemistry (ICC), making it a versatile choice for various experimental setups. Additionally, we offer the recombinant antibody, Anti-LIF antibody [EPR28693-84] (ab320821). This monoclonal antibody is validated for use in Western blotting (WB) and provides the consistency that comes with recombinant products. Together, these antibodies provide robust options for studying LIF in your research. The Recombinant Human LIF protein (Active) ELISA Kit (ab287941) is an excellent option for researchers looking to measure LIF in their experiments.
Abcam Product Citation Summary
The data indicates that LIF (Leukaemia Inhibitory Factor) is being studied in the context of inflammatory markers, particularly in the hypothalamus of mice. The use of both western blotting and immunohistochemistry suggests a thorough investigation of LIF's expression and localisation in this biological context.
Abcam Product Citation Table
Function
LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
Sequence Similarities
Belongs to the LIF/OSM family.
Cellular localization
- Secreted
Alternative names
HILDA, LIF, Leukemia inhibitory factor, Differentiation-stimulating factor, Melanoma-derived LPL inhibitor, D factor, MLPLI