Lif
Function
LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
Sequence Similarities
Belongs to the LIF/OSM family.
Cellular localization
- Secreted
Alternative names
Leukemia inhibitory factor, LIF, Differentiation-stimulating factor, D factor, Lif