PINCH 1

Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration.

Expressed in most tissues except in the brain.

• Cell junction
• Focal adhesion
• Cell membrane
• Peripheral membrane protein
• Cytoplasmic side

PINCH, PINCH1, LIMS1, LIM and senescent cell antigen-like-containing domain protein 1, Particularly interesting new Cys-His protein 1, Renal carcinoma antigen NY-REN-48, PINCH-1

• entrezGene:3987
• omim:602567
• swissprot:P48059

Proteins

Immunology & Infectious Disease

37251Da