LIMS1
Function
Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration.
Tissue Specificity
Expressed in most tissues except in the brain.
Cellular localization
- Cell junction
- Focal adhesion
- Cell membrane
- Peripheral membrane protein
- Cytoplasmic side
Alternative names
PINCH, PINCH1, LIMS1, LIM and senescent cell antigen-like-containing domain protein 1, Particularly interesting new Cys-His protein 1, Renal carcinoma antigen NY-REN-48, PINCH-1