LIPC
Function
Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein particles (PubMed:12032167, PubMed:26193433, PubMed:7592706, PubMed:8798474). Also exhibits lysophospholipase activity (By similarity). Can hydrolyze both neutral lipid and phospholipid substrates but shows a greater binding affinity for neutral lipid substrates than phospholipid substrates (By similarity). In native LDL, preferentially hydrolyzes the phosphatidylcholine species containing polyunsaturated fatty acids at sn-2 position (PubMed:26193433).
Involvement in disease
Hepatic lipase deficiency
HL deficiency
A disorder characterized by elevated levels of beta-migrating very low density lipoproteins, and abnormally triglyceride-rich low and high density lipoproteins.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the AB hydrolase superfamily. Lipase family.
Cellular localization
- Secreted
Alternative names
HTGL, LIPC, Hepatic triacylglycerol lipase, HL, Hepatic lipase, Lipase member C, Lysophospholipase, Phospholipase A1