Lire1
Domain
The coiled coil domain mediates homotrimerization.
The RRM and the CTD domain are both required for proper RNA-binding activity.
Function
Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded.
Post-translational modifications
Polyubiquitinated, probably by UBR2, which induces its degradation.
Sequence Similarities
Belongs to the transposase 22 family.
Tissue Specificity
Expressed in meiotic spermatocytes and in the cerebellum (at protein level).
Cellular localization
- Nucleus
- Nucleolus
- Cytoplasm
- Cytoplasm
- Cytoplasmic ribonucleoprotein granule
- Cytoplasm
- Stress granule
- Colocalizes with its encoding RNA in cytoplasmic ribonucleoprotein particle. Mainly cytoplasmic, rarely detected in the nucleus, possibly within the nucleolus.
Alternative names
LINE-1 retrotransposable element ORF1 protein, L1-ORF1p, LINE retrotransposable element 1, LINE1 retrotransposable element 1, Transposase element L1Md-A101/L1Md-A102/L1Md-A2, Lire1