Lire1

The coiled coil domain mediates homotrimerization.

The RRM and the CTD domain are both required for proper RNA-binding activity.

Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded.

Polyubiquitinated, probably by UBR2, which induces its degradation.

Belongs to the transposase 22 family.

Expressed in meiotic spermatocytes and in the cerebellum (at protein level).

• Nucleus
• Nucleolus
• Cytoplasm
• Cytoplasm
• Cytoplasmic ribonucleoprotein granule
• Cytoplasm
• Stress granule
• Colocalizes with its encoding RNA in cytoplasmic ribonucleoprotein particle. Mainly cytoplasmic, rarely detected in the nucleus, possibly within the nucleolus.

LINE-1 retrotransposable element ORF1 protein, L1-ORF1p, LINE retrotransposable element 1, LINE1 retrotransposable element 1, Transposase element L1Md-A101/L1Md-A102/L1Md-A2, Lire1

• swissprot:P11260

Proteins

Immunology & Infectious Disease

41226Da