LMCD1
Domain
The LIM zinc-binding domains and the Cys-rich region mediate interaction with GATA6.
Function
Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.
Tissue Specificity
Expressed in the heart (at protein level). Expressed in many tissues with highest abundance in skeletal muscle.
Cellular localization
- Cytoplasm
- Nucleus
- May shuttle between the cytoplasm and the nucleus.
Alternative names
LIM and cysteine-rich domains protein 1, Dyxin, LMCD1