LMO1
Function
May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.
Involvement in disease
A chromosomal aberration involving LMO1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p15;q11) with TCRD.
Tissue Specificity
Expressed mainly in the central nervous. Low level of expression in other tissues including thymus.
Cellular localization
- Nucleus
Alternative names
RBTN1, RHOM1, TTG1, LMO1, Rhombotin-1, Cysteine-rich protein TTG-1, LIM domain only protein 1, T-cell translocation protein 1, LMO-1