Lmo4
Developmental stage
Expressed in the developing spinal cord in the ventricular zone and down-regulated in the lateral zone at 11.5 dpc (at protein level) (PubMed:18539116). Highly expressed in motor neurons that emerge from the ventricular zone at 11.5 dpc (at protein level) (PubMed:18539116). At 12.5 dpc, highly expressed in motor neurons in medial median motor column (MMCm), which innervate dorsal axial muscles (PubMed:18539116).
Function
Transcription cofactor (PubMed:18539116). Plays a role in establishing motor neuron identity, in concert with MNX1, acting, at least in part, to disrupt LDB1-LHX3 complexes thereby negatively modulating interneuron genes in motor neurons (PubMed:18539116).
Tissue Specificity
Expressed in a wide variety of tissues.
Alternative names
LIM domain transcription factor LMO4, Breast tumor autoantigen, LIM domain only protein 4, LMO-4, Lmo4