LMTK3
Function
Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity).
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family.
Cellular localization
- Membrane
- Single-pass membrane protein
- Cell projection
- Axon
- Cell projection
- Dendrite
- Golgi apparatus membrane
- Punctate pattern in cell projections.
Alternative names
KIAA1883, TYKLM3, LMTK3, Serine/threonine-protein kinase LMTK3, Lemur tyrosine kinase 3