Low-density lipoprotein receptor
Domain
The NPXY motif mediates the interaction with the clathrin adapter DAB2 and with LDLRAP1 which are involved in receptor internalization. A few residues outside the motif also play a role in the interaction.
Function
Binds low density lipoprotein /LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Forms a ternary complex with PGRMC1 and TMEM97 receptors which increases LDLR-mediated LDL internalization.
Post-translational modifications
N- and O-glycosylated.
Ubiquitinated by MYLIP leading to degradation.
Sequence Similarities
Belongs to the LDLR family.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
- Membrane
- Clathrin-coated pit
- Golgi apparatus
- Early endosome
- Late endosome
- Lysosome
- Rapidly endocytosed upon ligand binding.
Alternative names
Low-density lipoprotein receptor, LDL receptor, Ldlr