LDLR

The NPXY motif mediates the interaction with the clathrin adapter DAB2 and with LDLRAP1 which are involved in receptor internalization. A few residues outside the motif also play a role in the interaction.

Binds low density lipoprotein /LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Forms a ternary complex with PGRMC1 and TMEM97 receptors which increases LDLR-mediated LDL internalization.

N- and O-glycosylated.

Ubiquitinated by MYLIP leading to degradation.

Belongs to the LDLR family.

• Cell membrane
• Single-pass type I membrane protein
• Membrane
• Clathrin-coated pit
• Golgi apparatus
• Early endosome
• Late endosome
• Lysosome
• Rapidly endocytosed upon ligand binding.

Low-density lipoprotein receptor, LDL receptor, Ldlr

• entrezGene:16835
• swissprot:P35951

Proteins

Metabolism

94947Da