LOXL4
Function
Catalyzes the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin, resulting in the formation of covalent cross-linkages, and the stabilization of collagen and elastin fibers.
Post-translational modifications
The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
May be proteolytically cleaved by BMP1.
Sequence Similarities
Belongs to the lysyl oxidase family.
Tissue Specificity
Expressed in many tissues, the highest levels among the tissues studied being in the skeletal muscle, testis and pancreas. Expressed in cartilage.
Cellular localization
- Secreted
- Extracellular space
Alternative names
LOXC, LOXL4, Lysyl oxidase homolog 4, Lysyl oxidase-like protein 4, Lysyl oxidase-related protein C