Loxl4
Function
Catalyzes the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin, resulting in the formation of covalent cross-linkages, and the stabilization of collagen and elastin fibers.
Post-translational modifications
The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
May be proteolytically cleaved by BMP1.
Sequence Similarities
Belongs to the lysyl oxidase family.
Cellular localization
- Secreted
- Extracellular space
Alternative names
Loxc, Loxl4, Lysyl oxidase homolog 4, Lysyl oxidase-like protein 4, Lysyl oxidase-related protein C