LPAR3
Function
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity
Most abundantly expressed in prostate, testes, pancreas, and heart, with moderate levels in lung and ovary. No detectable expression in brain, placenta, liver, skeletal muscle, kidney, spleen, thymus, small intestine, colon, or peripheral blood leukocytes.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
EDG7, LPA3, LPAR3, Lysophosphatidic acid receptor 3, LPA receptor 3, LPA-3, Lysophosphatidic acid receptor Edg-7