LPAR4
Function
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA.
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity
High expression in ovary. Not detected in the brain regions thalamus, putamen, caudate, frontal cortex, pons, hypothalamus and hippocampus.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
GPR23, LPA4, P2RY9, LPAR4, Lysophosphatidic acid receptor 4, LPA receptor 4, LPA-4, G-protein coupled receptor 23, P2Y purinoceptor 9, P2Y5-like receptor, Purinergic receptor 9, P2Y9