Lrfn5
Developmental stage
Expression starts around 11.5-12.5 dpc. At 11.5 dpc, detected in the outer layer of the telencephalic vesicles. This pattern of expression continues until 17.5 dpc with expression in the cortical plate, but not in the inner layer of the cerebral cortex, including subplate, ventricular zone, and subventricular zone. As also detected in the hippocampus, amygdala and widely in diencephalic nuclei.
Domain
Lacks a cytoplasmic PDZ-binding motif, which has been implicated in function of related LRFN proteins.
Function
Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons (By similarity).
Post-translational modifications
Glycosylated.
Sequence Similarities
Belongs to the LRFN family.
Tissue Specificity
Predominantly expressed in the brain, with a weak, but broad expression in the cerebral cortex and diencephalic nuclei. Strongly expressed in both the pyramidal layer and the dentate gyrus of the hippocampus. Also detected in other parts of the central nervous system, including the olfactory bulb, pons, cerebellum, and medulla oblongata, as well as in the peripheral nervous system, such as the ganglia of cranial nerves and the dorsal root ganglion during gestation.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
Kiaa4208, Salm5, Lrfn5, Leucine-rich repeat and fibronectin type-III domain-containing protein 5