LRPAP1
Function
Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway.
Involvement in disease
Myopia 23, autosomal recessive
MYP23
A refractive error of the eye, in which parallel rays from a distant object come to focus in front of the retina, vision being better for near objects than for far.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
N-glycosylated.
Sequence Similarities
Belongs to the alpha-2-MRAP family.
Cellular localization
- Rough endoplasmic reticulum lumen
- Endoplasmic reticulum-Golgi intermediate compartment lumen
- Golgi apparatus
- cis-Golgi network
- Golgi apparatus lumen
- Endosome lumen
- Cell surface
- May be associated with receptors at the cell surface.
Alternative names
A2MRAP, LRPAP1, Alpha-2-macroglobulin receptor-associated protein, Alpha-2-MRAP, Low density lipoprotein receptor-related protein-associated protein 1, RAP