Alpha-2-macroglobulin receptor-associated protein

Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway.

N-glycosylated.

Belongs to the alpha-2-MRAP family.

Highly expressed in PYS-2 parietal endoderm cells and in the kidney. The RNA level increased about 10-fold during differentiation of F9 embryonal carcinoma cells to parietal endoderm cells.

• Rough endoplasmic reticulum lumen
• Endoplasmic reticulum-Golgi intermediate compartment lumen
• Golgi apparatus
• cis-Golgi network
• Golgi apparatus lumen
• Endosome lumen
• Cell surface
• May be associated with receptors at the cell surface.

Alpha-2-macroglobulin receptor-associated protein, Alpha-2-MRAP, Heparin-binding protein 44, Low density lipoprotein receptor-related protein-associated protein 1, HBP-44, RAP, Lrpap1

• entrezGene:16976
• swissprot:P55302

Proteins

Immunology & Infectious Disease

42215Da