Lrpap1
Function
Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway.
Post-translational modifications
N-glycosylated.
Sequence Similarities
Belongs to the alpha-2-MRAP family.
Tissue Specificity
Highly expressed in PYS-2 parietal endoderm cells and in the kidney. The RNA level increased about 10-fold during differentiation of F9 embryonal carcinoma cells to parietal endoderm cells.
Cellular localization
- Rough endoplasmic reticulum lumen
- Endoplasmic reticulum-Golgi intermediate compartment lumen
- Golgi apparatus
- cis-Golgi network
- Golgi apparatus lumen
- Endosome lumen
- Cell surface
- May be associated with receptors at the cell surface.
Alternative names
Alpha-2-macroglobulin receptor-associated protein, Alpha-2-MRAP, Heparin-binding protein 44, Low density lipoprotein receptor-related protein-associated protein 1, HBP-44, RAP, Lrpap1