LRRC19
Function
Pathogen-recognition receptor which mediates the activation of TRAF2- and TRAF6 NF-kappa-B signaling pathways and induces the expression of pro-inflammatory cytokines (PubMed:19679103, PubMed:25026888). In kidney, prevents infection by uropathogenic bacteria by inducing the production of cytokines, chemokines and antimicrobial substances. In gut, involved in host-microbiota interactions, plays a critical role in promoting the recruitment of immune cells and intestinal inflammation (By similarity).
Tissue Specificity
Expressed in renal collecting duct epithelial cells.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
Leucine-rich repeat-containing protein 19, LRRC19