LRRC4
Domain
The last 4 C-terminal residues bind to the first 2 PDZ domains of DLG4.
Function
Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays an important role for auditory synaptic responses. Involved in the suppression of glioma (By similarity).
Post-translational modifications
N-glycosylated.
Tissue Specificity
Specifically expressed in brain.
Cellular localization
- Membrane
- Single-pass type I membrane protein
- Postsynaptic cell membrane
- LRRC4 and DLG4 are interdependent for synaptic localization.
Alternative names
BAG, NAG14, UNQ554/PRO1111, LRRC4, Leucine-rich repeat-containing protein 4, Brain tumor-associated protein BAG, Nasopharyngeal carcinoma-associated gene 14 protein, Netrin-G2 ligand, NGL-2