LRRC45
Function
Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion.
Post-translational modifications
Phosphorylated by NEK2 during misosis, phosphorylation reduces centrosomal localization which subsequently leads to centrosome separation.
Cellular localization
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Centrosome
- Localizes to the proteinaceous linker between the proximal ends of the centrioles.
Alternative names
Leucine-rich repeat-containing protein 45, LRRC45