LRRFIP1
Developmental stage
Widely expressed in fetal tissues.
Domain
The DNA-binding domain is intrinsically unstructured.
The coiled coil mediates dimerization.
Function
Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
Sequence Similarities
Belongs to the LRRFIP family.
Tissue Specificity
Ubiquitously expressed.
Cellular localization
- Nucleus
- Cytoplasm
Alternative names
GCF2, TRIP, LRRFIP1, Leucine-rich repeat flightless-interacting protein 1, LRR FLII-interacting protein 1, GC-binding factor 2, TAR RNA-interacting protein