LRRFIP2
Function
May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
Post-translational modifications
Ser-190 and Ser-202 are phosphorylated in response to LPS stimulation. Ser-202 phosphorylation regulates the LPS-induced interaction with MYD88.
Sequence Similarities
Belongs to the LRRFIP family.
Tissue Specificity
Widely expressed, with highest levels in heart and skeletal muscle.
Alternative names
Leucine-rich repeat flightless-interacting protein 2, LRR FLII-interacting protein 2, LRRFIP2