LRRTM2
Domain
Synaptogenic effects are mediated by the extracellular LRR region.
Function
Involved in the development and maintenance of excitatory synapses in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity).
Sequence Similarities
Belongs to the LRRTM family.
Tissue Specificity
Expressed in neuronal tissues.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
- Postsynaptic cell membrane
- Single-pass type I membrane protein
- Localized to excitatory synapses.
Alternative names
KIAA0416, LRRN2, LRRTM2, Leucine-rich repeat transmembrane neuronal protein 2, Leucine-rich repeat neuronal 2 protein