Leucine-rich repeat transmembrane neuronal protein 2

Synaptogenic effects are mediated by the extracellular LRR region.

Involved in the development and maintenance of excitatory synapses in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity).

Belongs to the LRRTM family.

Expressed in neuronal tissues.

• Cell membrane
• Single-pass type I membrane protein
• Postsynaptic cell membrane
• Single-pass type I membrane protein
• Localized to excitatory synapses.

KIAA0416, LRRN2, LRRTM2, Leucine-rich repeat transmembrane neuronal protein 2, Leucine-rich repeat neuronal 2 protein

• entrezGene:26045
• omim:610868
• swissprot:O43300

Proteins

Immunology & Infectious Disease

59076Da