LSM14A
Domain
The LSM14 domain and the RGG repeats are required for accumulation in P-bodies, and the region containing the FDF motif is responsible for cytoplasmic retention.
Function
Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800).
Sequence Similarities
Belongs to the LSM14 family.
Cellular localization
- Cytoplasm
- P-body
- Cytoplasm
- Cytoskeleton
- Spindle
- Cytoplasm
- Stress granule
Alternative names
C19orf13, FAM61A, RAP55, RAP55A, LSM14A, Protein LSM14 homolog A, Protein FAM61A, Protein SCD6 homolog, Putative alpha-synuclein-binding protein, RNA-associated protein 55A, AlphaSNBP, hRAP55, hRAP55A