LSM14B
Function
mRNA-binding protein essential for female fertility, oocyte meiotic maturation and the assembly of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes. Ensures the proper accumulation and clearance of mRNAs essential for oocyte meiotic maturation and the normal progression from Meiosis I to Meiosis II in oocytes. Promotes the translation of some oogenesis-related mRNAs. Regulates the expression and/or localization of some key P-body proteins in oocytes. Essential for the assembly of the primordial follicle in the ovary.
Sequence Similarities
Belongs to the LSM14 family.
Cellular localization
- Cytoplasm
- Cytoplasmic ribonucleoprotein granule
- Localizes to MARDO (mitochondria-associated ribonucleoprotein domain), a mitochondria-associated membraneless compartment that stores mRNAs in oocytes.
Alternative names
C20orf40, FAM61B, RAP55B, LSM14B, Protein LSM14 homolog B, RNA-associated protein 55B, hRAP55B