LSM5

Function

Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).

Sequence similarities

Belongs to the snRNP Sm proteins family.

Cellular localization

• Nucleus

Alternative names

• U6 snRNA-associated Sm-like protein LSm5
• LSM5

Database links

• entrezGene:23658
• omim:607285
• swissprot:Q9Y4Y9

Target type

Proteins

Primary research area

Metabolism

Molecular weight

9937Da