LST1
Function
Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation.
Sequence Similarities
Belongs to the LST1 family.
Tissue Specificity
Expressed in lung, tonsil, thymus, placenta, kidney, fetal spleen, fetal liver and brain.
Cellular localization
- Membrane
- Single-pass membrane protein
- Golgi apparatus membrane
- Single-pass membrane protein
- Endomembrane system
- Single-pass membrane protein
- Also detected in a perinuclear region corresponding to the localization of the Golgi apparatus and throughout the cytoplasm.
Alternative names
B144, LST1, Leukocyte-specific transcript 1 protein, Protein B144