Lta
Function
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
Sequence Similarities
Belongs to the tumor necrosis factor family.
Cellular localization
- Secreted
- Membrane
- The homotrimer is secreted. The heterotrimer is membrane-associated.
Alternative names
Tnfb, Tnfsf1, Lta, Lymphotoxin-alpha, LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1