Lta

Function

Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (PubMed:9462508). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.

Involvement in disease

Psoriatic arthritis

PSORAS

An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).

None

Disease susceptibility is associated with variants affecting the gene represented in this entry.

Sequence similarities

Belongs to the tumor necrosis factor family.

Cellular localization

• Secreted
• Membrane
• The homotrimer is secreted. The heterotrimer is membrane-associated.

Alternative names

• Lymphotoxin-alpha
• LT-alpha
• TNF-beta
• Tumor necrosis factor ligand superfamily member 1
• LTA
• TNFSF1
• TNFB

Database links

• entrezGene:4049
• omim:153440
• swissprot:P01374

Target type

Proteins

Molecular weight

22297Da