LUC7L3
Function
Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing.
Post-translational modifications
Phosphorylated in vitro by SRPK1, SRPK2 and CLK1.
Sequence Similarities
Belongs to the Luc7 family.
Tissue Specificity
Widely expressed. Highest levels in heart, brain, pancreas, thymus, ovary, small intestine and peripheral blood leukocytes, as well as cerebellum, putamen and pituitary gland. Lowest levels in lung, liver and kidney. Also expressed in fetal tissues, including brain, heart, kidney, thymus and lung.
Cellular localization
- Nucleus speckle
- The subnuclear localization is affected by cisplatin.
Alternative names
CREAP1, CROP, O48, LUC7L3, Luc7-like protein 3, Cisplatin resistance-associated-overexpressed protein, Luc7A, Okadaic acid-inducible phosphoprotein OA48-18, cAMP regulatory element-associated protein 1, CRE-associated protein 1, CREAP-1