lukE
Function
Part of a bi-component leucotoxin that acts by forming pores in the membrane of the target cells. LukE-LukD is as effective as the Panton-Valentine leucocidin (PVL) for inducing dermonecrosis when injected in the rabbit skin, but not hemolytic and poorly leucotoxic on human blood cells compared to other leucotoxins expressed by S.aureus.
Sequence Similarities
Belongs to the aerolysin family.
Cellular localization
- Secreted
Alternative names
Leucotoxin LukE, lukE