Lupus La protein

GeneName

SSB

Summary

SSB, also known as single stranded DNA binding protein or helix destabilizing protein, is a 47kDa protein that plays a pivotal role in RNA metabolism and processing. It is expressed in various cellular compartments including the nucleus, cytoplasm, and cytoplasmic stress granules. SSB is involved in multiple RNA-related functions, such as mRNA binding, tRNA binding, and facilitating the processing and export of tRNA. Additionally, it participates in the regulation of translation and the catabolism of histone mRNA, highlighting its importance in gene expression regulation and cellular stress responses.

Importance

SSB is relevant to: - RNA metabolism and processing, which is essential for proper gene expression - The regulation of translation, influencing protein synthesis in response to cellular conditions - Stress granule dynamics, playing a role in cellular responses to stress - Viral translational initiation, contributing to our understanding of viral replication mechanisms - tRNA processing and modification, crucial for accurate protein translation

Top Products

For researchers investigating SSB, we recommend two excellent primary antibodies. The first is the well-cited Anti-SSB antibody [mAbcam75927] (ab75927), a trusted monoclonal antibody that has garnered 12 citations. It is highly effective across a range of applications, including Western blotting (WB), immunohistochemistry (IHC), immunocytochemistry (ICC), immunoprecipitation (IP), and flow cytometry (FC). This versatility makes it a reliable choice for various experimental needs.Additionally, we offer the recombinant Anti-SSB antibody [EPR6570] (ab124932), which is validated for use in WB and IHC. With 3 citations, this recombinant antibody provides the batch-to-batch consistency that many researchers seek. Together, these antibodies provide robust options for studying SSB in your research.

Abcam Product Citation Summary

The SSB antibody (ab75927) has been utilised in various studies focusing on viral replication and multiple sclerosis. The research primarily involves human cells, including PBMCs, indicating the relevance of SSB in immune responses and viral infections.

Abcam Product Citation Table

Function

Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:2470590, PubMed:3192525). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597).

Post-translational modifications

Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein.

The N-terminus is blocked.

Cellular localization

• Nucleus

Alternative names

Lupus La protein, La autoantigen, La ribonucleoprotein, Sjoegren syndrome type B antigen, SS-B, SSB

Database links

swissprot:P05455 omim:109090 genbank:NP_003133.1 entrezGene:6741