Ly6e
Function
GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation (PubMed:8642345, PubMed:9575182). Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation (PubMed:9575182). Restricts the entry of murine coronavirus, mouse hepatitis virus, by interfering with spike protein-mediated membrane fusion (PubMed:32704094). Also plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA) (PubMed:28679758). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta (PubMed:29500366). May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response (PubMed:26276394).
Tissue Specificity
Ubiquitously expressed in mouse adult tissues with maximal expression in the lung and the salivary gland. Expression is strikingly lower in the fetal tissues except for the placenta (PubMed:28679758). Present in thymus where its expression is observed in immature thymocytes and thymic stromal cells (PubMed:1531995). Also found on functionally active T-cells as well as B-cells and thymic dendritic cells (PubMed:2987354).
Cellular localization
- Cell membrane
- Lipid-anchor
- GPI-anchor
Alternative names
Ly67, Sca-2, Tsa-1, Ly6e, Lymphocyte antigen 6E, Ly-6E, Stem cell antigen 2, Thymic shared antigen 1, TSA-1