LY75

Function

Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.

Post-translational modifications

N-glycosylated.

Tissue Specificity

Expressed in spleen, thymus, colon and peripheral blood lymphocytes. Detected in myeloid and B-lymphoid cell lines. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.

Cellular localization

• Membrane
• Single-pass type I membrane protein

Alternative names

CD205, CLEC13B, LY75, Lymphocyte antigen 75, Ly-75, C-type lectin domain family 13 member B, DEC-205, gp200-MR6

Database links

swissprot:O60449 entrezGene:4065 omim:604524 entrezGene:100526664