LY75

Function

Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.

Post-translational modifications

N-glycosylated.

Tissue specificity

Expressed in spleen, thymus, colon and peripheral blood lymphocytes. Detected in myeloid and B-lymphoid cell lines. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.

Cellular localization

• Membrane
• Single-pass type I membrane protein

Alternative names

• LY75
• CD205
• LY 75
• Ly-75
• gp200
• CD 205
• DEC205
• CLEC13B
• DEC 205
• DEC-205
• CLEC 13B
• gp200 MR6
• gp200-MR6
• LY75_HUMAN
• CD205 antigen
• Lymphocyte antigen 75
• Renal Cell Carcinoma (gp200)
• C-type lectin domain family 13 member B

Database links

• entrezGene:4065
• entrezGene:17076
• entrezGene:499800
• entrezGene:100526664
• omim:604524
• swissprot:O60449
• swissprot:Q60767

Target type

Proteins

Molecular weight

215781Da