MD2

Function

Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581).

Post-translational modifications

N-glycosylated; high-mannose.

Cellular localization

• Secreted
• Extracellular space
• Secreted
• Retained in the extracellular space at the cell surface by interaction with TLR4 (PubMed:10359581).

Alternative names

• Lymphocyte antigen 96
• Ly-96
• ESOP-1
• Protein MD-2
• LY96
• ESOP1
• MD2

Database links

• entrezGene:23643
• omim:605243
• swissprot:Q9Y6Y9

Target type

Proteins

Molecular weight

18546Da