MD2

Binds bacterial lipopolysaccharide (LPS) (PubMed:17569869, PubMed:17803912). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581).

N-glycosylated; high-mannose.

• Secreted
• Extracellular space
• Secreted
• Retained in the extracellular space at the cell surface by interaction with TLR4 (PubMed:10359581).

ESOP1, MD2, LY96, Lymphocyte antigen 96, Ly-96, ESOP-1, Protein MD-2

• entrezGene:23643
• omim:605243
• swissprot:Q9Y6Y9

Proteins

Immunology & Infectious Disease

18546Da