Ly96
Function
Binds bacterial lipopolysaccharide (LPS) (PubMed:22532668). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10725698).
Post-translational modifications
N-glycosylated.
Tissue Specificity
Highly expressed in spleen, bone marrow, thymus, liver, kidney, ovary and decidua. Detected at lower levels in testis, small intestine and skin.
Cellular localization
- Secreted
- Extracellular space
- Secreted
- Retained in the extracellular space at the cell surface by interaction with TLR4.
Alternative names
Esop1, Md2, Ly96, Lymphocyte antigen 96, Ly-96, ESOP-1, Protein MD-2