LYPD3
Function
Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression.
Post-translational modifications
N-glycosylated and O-glycosylated.
Tissue Specificity
Expressed in placenta, skin and urothelium. Found in suprabasal keratinocytes of chronic wounds. Weak expression is found in esophagus and peripheral blood mononuclear cells. Found in the majority of primary and metastatic transitional cell carcinomas (TCCs) and as well in breast cancer tissues, but not in adjacent normal tissues. High expression is found in the tumor component of some noninvasive superficial lesions and in invasive and metastatic urothelial cancers.
Cellular localization
- Cell membrane
- Lipid-anchor
- GPI-anchor
Alternative names
C4.4A, UNQ491/PRO1007, LYPD3, Ly6/PLAUR domain-containing protein 3, GPI-anchored metastasis-associated protein C4.4A homolog, Matrigel-induced gene C4 protein, MIG-C4