LYVE1

Abundantly expressed in mesenteric lymphatic vessels at 16.5 dpc, with expression decreasing at 18.5 dpc (at protein level) (PubMed:28179430). Expressed in dermal lymphatic endothelial cells at 16.5 and 18.5 dpc (at protein level) (PubMed:28179430).

Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes (PubMed:10187853). Binds to pericelluar hyaluronan matrices deposited on the surface of leukocytes and facilitates cell adhesion and migration through lymphatic endothelium (By similarity).

O-glycosylated.

• Membrane
• Single-pass type I membrane protein
• Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface.

Crsbp1, Xlkd1, Lyve1, Lymphatic vessel endothelial hyaluronic acid receptor 1, LYVE-1, Cell surface retention sequence-binding protein 1, Extracellular link domain-containing protein 1, CRSBP-1

• entrezGene:114332
• swissprot:Q8BHC0

Proteins

Immunology & Infectious Disease

34574Da