LYVE1

Function

Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.

Post-translational modifications

O-glycosylated.

Tissue specificity

Mainly expressed in endothelial cells lining lymphatic vessels.

Cellular localization

• Membrane
• Single-pass type I membrane protein
• Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface.

Alternative names

• Lymphatic vessel endothelial hyaluronic acid receptor 1
• LYVE-1
• Cell surface retention sequence-binding protein 1
• Extracellular link domain-containing protein 1
• Hyaluronic acid receptor
• CRSBP-1
• UNQ230/PRO263
• XLKD1
• HAR
• CRSBP1
• LYVE1

Database links

• entrezGene:10894
• omim:605702
• swissprot:Q9Y5Y7

Target type

Proteins

Molecular weight

35213Da