M
Domain
Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins. Matrix protein contains one L domain: a PPXY motif which potentially interacts with the WW domain 3 of NEDD4 E3 ubiquitin ligase (Potential).
Function
Plays a major role in assembly, budding and uncoating of virion after membrane fusion. Completely covers the ribonucleoprotein coil and keep it in condensed bullet-shaped form. Inhibits viral transcription and stimulates replication. Plays a major role in early induction of TRAIL-mediated apoptosis in infected neurons (By similarity). Inhibits the integrated stress response (ISR) in the infected cell by blocking the formation of stress granules (By similarity).
Sequence Similarities
Belongs to the lyssavirus matrix protein family.
Cellular localization
- Virion membrane
- Peripheral membrane protein
- Host endomembrane system
- Peripheral membrane protein
- Host cytoplasm
Alternative names
Matrix protein, Phosphoprotein M2, M