M6PR

Domain

The extracellular domain is homologous to the repeating units (of approximately 147 AA) of the cation-independent mannose 6-phosphate receptor.

Function

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.

Cellular localization

• Lysosome membrane
• Single-pass type I membrane protein

Alternative names

• Cation-dependent mannose-6-phosphate receptor
• CD Man-6-P receptor
• CD-MPR
• 46 kDa mannose 6-phosphate receptor
• MPR 46
• MPRD
• MPR46
• M6PR

Database links

• entrezGene:4074
• omim:154540
• swissprot:P20645

Target type

Proteins

Primary research area

Neuroscience

Molecular weight

30993Da