In the developing pancreas, expressed exclusively in the insulin-positive cells from 13.5 dpc onward and never in the glucagon-expressing cells (at protein level) (PubMed:14973194). At 12.5dpc, at the mRNA level, detected in each formed somite, in myotomal cells. Also detected in the head neural tube, liver cells and, at low levels, in some mesenchyme-like cells (PubMed:14680841).
Transcriptional factor that activates insulin gene expression (PubMed:12368292, PubMed:15665000). Acts synergistically with NEUROD1/BETA2 and PDX1 (PubMed:15665000). Binds the insulin enhancer C1/RIPE3b element (PubMed:12917329, PubMed:14680841, PubMed:14973194, PubMed:15665000). Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence (By similarity).
Ubiquitinated, leading to its degradation by the proteasome.
Phosphorylated at tyrosines.
Belongs to the bZIP family. Maf subfamily.
Expressed in brain, lung, spleen, pancreas and kidney (PubMed:12368292, PubMed:14680841). In the pancreas, expressed in the insulin-producing beta-cells of the islets of Langerhans (at protein level) (PubMed:12917329, PubMed:15923615). Also expressed in the eye (PubMed:12368292, PubMed:15923615).
Transcription factor MafA, Pancreatic beta-cell-specific transcriptional activator, V-maf musculoaponeurotic fibrosarcoma oncogene homolog A, Mafa
Proteins
Immunology & Infectious Disease
37576Da
We found 1 product in 1 category