MAGEA1

Function

May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.

Tissue Specificity

Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. Never expressed in kidney tumors, leukemias and lymphomas.

Cellular localization

• Cytoplasm
• Nucleus

Alternative names

MAGE1, MAGE1A, MAGEA1, Melanoma-associated antigen 1, Antigen MZ2-E, Cancer/testis antigen 1.1, MAGE-1 antigen, CT1.1

Database links

swissprot:P43355 omim:300016 entrezGene:4100

Other research areas

• Immuno-oncology