Maged1

Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA coregulator, modulating the expression of core clock genes such as BMAL1 and NFIL3, induced, or NR1D1, repressed.

Ubiquitously expressed in many adult tissues, except for the spleen. Expressed in osteoblastic and chondrogenic cell lines and also during embryonic development.

• Nucleus
• Cytoplasm
• Cell membrane
• Peripheral membrane protein
• Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF.

Nrage, Melanoma-associated antigen D1, Dlxin-1, MAGE-D1 antigen, Neurotrophin receptor-interacting MAGE homolog

• swissprot:Q9QYH6

Proteins

Immunology & Infectious Disease

85670Da