MAGI1
Function
Plays a role in coupling actin fibers to cell junctions in endothelial cells, via its interaction with AMOTL2 and CDH5 (By similarity). May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity).
Tissue Specificity
Widely expressed with the exception of skeletal muscle. Isoform 1, isoform 2 and isoform 6 are highly expressed in colon, kidney, lung, liver, and pancreas. Isoform 5 is predominantly expressed in brain and heart. Isoform 3 and isoform 4 are highly expressed in pancreas and brain.
Cellular localization
- Cell junction
- Tight junction
- Cell membrane
- Peripheral membrane protein
- Localizes to epithelial cells tight junctions.
Alternative names
AIP3, BAIAP1, BAP1, TNRC19, MAGI1, Atrophin-1-interacting protein 3, BAI1-associated protein 1, Membrane-associated guanylate kinase inverted 1, Trinucleotide repeat-containing gene 19 protein, WW domain-containing protein 3, AIP-3, BAP-1, MAGI-1, WWP3