MAGI3
Function
Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.
Post-translational modifications
Ubiquitinated following interaction with HPV E6 protein, leading to its degradation by the proteasome. Degradation is independent of E6AP ubiquitin ligase complex.
Sequence Similarities
Belongs to the MAGUK family.
Tissue Specificity
Widely expressed.
Cellular localization
- Cell membrane
- Peripheral membrane protein
- Cell junction
- Tight junction
- Nucleus
- Concentrates in specific sites at the plasma membrane and in the nucleus. In epithelial cells, it localizes at tight junctions (By similarity).
Alternative names
KIAA1634, MAGI3, Membrane-associated guanylate kinase inverted 3, MAGI-3