MAML1
Domain
The C-terminal region is required for transcriptional activation.
Function
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.
Sequence Similarities
Belongs to the mastermind family.
Tissue Specificity
Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen.
Cellular localization
- Nucleus speckle
- Nuclear, in a punctate manner.
Alternative names
KIAA0200, MAML1, Mastermind-like protein 1, Mam-1