MAML3
Domain
The C-terminal domain is required for transcriptional activation.
Function
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1.
Sequence Similarities
Belongs to the mastermind family.
Cellular localization
- Nucleus speckle
- Nuclear, in a punctate manner.
Alternative names
KIAA1816, MAML3, Mastermind-like protein 3, Mam-3