MAML3

Domain

The C-terminal domain is required for transcriptional activation.

Function

Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1.

Sequence similarities

Belongs to the mastermind family.

Cellular localization

• Nucleus speckle
• Nuclear, in a punctate manner.

Alternative names

• Mastermind-like protein 3
• Mam-3
• KIAA1816
• MAML3

Database links

• entrezGene:55534
• omim:608991
• swissprot:Q96JK9

Target type

Proteins

Molecular weight

122293Da