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Function

Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.

Pathway

Protein modification; protein glycosylation.

Post-translational modifications

Glycosylated.

Sequence similarities

Belongs to the glycosyl hydrolase 38 family.

Cellular localization

  • Golgi apparatus membrane
  • Single-pass type II membrane protein

Alternative names

MANA2, MAN2A1, Alpha-mannosidase 2, Golgi alpha-mannosidase II, Mannosidase alpha class 2A member 1, AMan II, Man II

Target type

Proteins

Primary research area

Immunology & Infectious Disease

Molecular weight

131141Da

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